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KMID : 0377519910160030315
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Chung-Ang Journal of Medicine
1991 Volume.16 No. 3 p.315 ~ p.323
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Induction of Superoxide Dismutase in the Lung of Mouse Infected with Mycobacterium scrofulaceum
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Abstract
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This study was undertaken to investigate whether the induction of superoxide dismutase in the lung was affected by infection with M. scrofulaceum. In addition, association between the plasmidbearing and induction of superoxide dismutase(SOD) were investigated with various strains of M. scrofulaceum. When M. scrofulaceum were injected to ICR JCL mouse intravenously, type 42 CDC 1198 and type 43 Brooks strains induced superoxide .dismutase to the lungs, which no significant changes in the activity, of superoxide dismutase in the spleen were observed. Strains of M. scrofulaceum which possessed a large plasmid(>80 Kb)induced much oxygen metabolites in the host than the plasmidless strains.
This reult suggests that more virulent strains of M. scrofulaceum induces the activity of superoxide dismutase in the host to protect the injuries from the reactive oxygen species during the infection.
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